ENTERIC VIRUSES

Rotavirus and Adenovirus are two of the most common causative agents of viral gastroenteritis. Microgen has developed a range of detection products based on high quality antibodies developed by our R&D team.

Rotavirus

Most immunological based assays for Rotavirus employ antibodies developed using bovine strains. MicrogenTM has developed highly specific antibodies which combine both bovine and pooled human strains of the virus ensuring reactivity with all commonly encountered serotypes.

Adenovirus

Adenovirus serogroups 40 and 41 are well established as the most common serogroups of Adenovirus related gastroenteritis. However, serogroups 12 – 17, 21, 25, 26, 29 and 31 have also been reported as causative agents. The MicrogenTM range of Adenovirus detection products are based on a genus specific hexon antigen which provides a broad activity antigen able to detect all serogroups.

These antibodies have been employed in a range of different formats providing products to meet the needs of every laboratory.

• Rotascreen® and Adenoscreen® Latex Agglutination Tests – rapid and simple latex agglutination tests able to deliver results within a few minutes.

• Rotascreen® and Adenoscreen® Rapid EIA – employing removable wells, this rapid EIA format is ideally suited to both low and high volume testing and is able to deliver results with less than 60 minutes total test time.

• Rotascreen® and Adenoscreen® Dipsticks – an immunochromatographic test strip format which is ideally
suited to situations which require rapid turn around time for results .

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SEROLOGY

Syphilis, Toxoplasma, Rubella and CMV

Microgen Bioproducts and MERCIATM have a long history of development and innovation of high quality serology kits. We are very pleased to announce the introduction of our new range Immunoglobulin G detection systems, MERCIATM RUBELLA G,
MERCIATM CMV G and MERCIATM TOXO G.

This new range of products offer a host of new features designed to simplify test performance and improve performance.

Features include:

• In-well dilution
• Colour coded reagents for increased security
• Liquid, ready-to-use reagents providing time savings and security
• Increased signal-to-noise ratio reducing the number of equivocal results
• Easily automated and quantitative
• Small kit size to assist with storage

MERCIATM Products currently available include:

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INFECTIOUS DISEASES SEROLOGY (Enzyme Immunoassay)
PANBIO – UK CUSTOMERS ONLY

An extensive range of Enzyme Immunoassays are available from PANBIO, Australia for the detection of antibodies to the following viruses and infectious agents.

* These products are NOT CE Marked

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INNOGENETICS

Microgen Bioproducts distributes the unique range of HIV/HTLV and Hepatitis B range of diagnostic test kits manufactured by INNOGENETICS. These products are only available for sale to UK customers.

INNOTest® SYSTEMS

INNOTest® Systems are a range of Enzyme Immunoassays employing synthetic peptides as antigens for the detection of antibodies to selected viral agents.

HIV Ag MAb. – an enzyme immunoassay for the detection and quantification of p24 antigen in human serum, plasma, or tissue culture supernatant. Highly specific antibodies to p24 to detect HIV-1, HIV-1 group O and HIV-2.

INNO-LIA® SYSTEMS

INNO-LIA® SYSTEMS are a range of line immunoassays that employ a range of antigens including recombinant proteins and synthetic peptides for the confirmation of specific antibodies to selected virus agents.

INNO-LIA SCORE The NEW INNO-LIA Score HTLV I/II, HIV and Syphilis are now available from Microgen Bioproducts Ltd. These products now include colour-coded reagents to avoid potential dilution errors or reagent misidentification up. In addition the conjugate and substrate are provided as ready-to-use reagents. Kit controls are provided as concentrates so that they are treated the same as patient samples and all Score products are CE marked. The HTLV I/II and HIV I/II products have the option of a 3 hour sample incubation, using 20µl sample instead of 10µl, as an alternative to the current overnight incubation.
INNO-LIA HIV I/11 Score – a line immunoassay for the confirmation and discrimination of antibodies to HIV-1, HIV-1 group O and HIV-2. Incorporates recombinant proteins and synthetic peptides from HIV-1 and HIV-2 and a synthetic peptide from HIV-1 group O. Suitable for serum and plasma. INNO-LIA HTLV I/II Score – a line immunoassay to confirm the presence of antibodies against human T-cell lymphotropic virus type 1 (HTLV-I) and type II in human serum or plasma. Incorporates recombinant proteins and synthetic peptides from HTLV I and II coated as discrete lines on a nylon strip with plastic backing. INNO-LIA Syphilis Score – line immunoassay for the confirmation of antibodies against Treponema pallidum in human serum and plasma. Three recombinant proteins (TpN47, TpN17 and TpN15) and one synthetic peptide (TmpA) are coated as discrete lines on a nylon strip with plastic backing. ANA Update – a line immunoassay for the detection and identification of autoantibodies in human serum against the following nuclear and cytoplasmic antigens: Sm (SmB and SmD), RNP (RNP-A and RNP-C), Ro52 and Ro60 (SSA), La/SSB, centromere (Cenp-B), Scl-70 (DNA topoisomerase), Jo-1, ribosomal P and histones. INNO-LiPA® SYSTEMS INNO-LiPA® Systems are a range of line probe assays for the detection wild type and mutant sequences in genes of specific viral agents. The presence of these mutations is associated with drug resistance to these agents.
HEPATITIS INVESTIGATIONS The INNO-LiPA Hepatitis B Genotyping, HBV DR and HBV PreCore products are now available from Microgen Bioproducts Ltd. These assays are all based on the reverse hybridisation principle where biotinylated DNA material is hybridised with specific oligonucleotide probes immobilised as parallel lines coated onto membrane strips.
INNO-Lipa HBV DR v2 - allows the simultaneous detection of Hepatitis B virus wild-type motif and lamuvidine resistance-associated mutations, all clinically relevant lamivudine and adefovir mutations, as well as known compensatory mutations . This test provides information on the emergence of drug resistance, viral breakthrough, changing or adding drugs after viral breakthrough, long term persistence of lamuvidine resistant mutations and causes of post transplant viral breakthrough. The new probe lines may also provide information on entecavir resistance.Each kit is provided with the necessary primers in order to amplify the specific target material for testing in the INNO-LiPA products. In addition the INNO-LiPA assays may be performed on the AUTO-LiPA which processes the strips from sample incubation to completion. FOR RESEARCH USE ONLY INNO-Lipa HBV Genotyping - allows identification of HBV genotypes A to H which provides information on disease progression, HbeAg seroconversion rate and response to interferon therapy. NOW CE MARKED INNO-Lipa HBV Pre-core – allows the simultaneous detection of Hepatitis B wild-type motif and mutations at the basal core promoter and precore region. This test provides information on interferon-alpha therapy response, fulminant hepatitis, rate of lamuvidine-resistant mutants and hepatocellular carcinomaLine probe assay for the simultaneous detection of HBV wild-type motif and mutations at the basal core promoter and pre core region. RESEARCH USE ONLY NEW RELEASE INNO-Lipa HPV Genotyping v2 - allows the identification of the 25 most clinically relevant human papillomavirus genotypes from individuals with current active HPV infections and those with persistent infections. This assay is able to readily simultaneously detect infections with multiple genotypes which occur in 25 - 30% of women who may later show an increased risk for the development of cervical cancer. Testing may be performed from a variety of sample types including cervical scrape, biopsy, glass slide or wax embedded samples. FOR RESEARCH USE ONLY

AUTOMATION IS AVAILABLE

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See BACTERIOLOGY for additional products in this range.